Title: MAN05 - Effects of ultra-long acting bronchodilator therapy assessed by impulse oscillometry in smoking asthmatics taking inhaled corticosteroids
Description: Cigarette smoking in asthma is associated with poorer asthma control and a higher frequency of asthma attacks. Asthma in smokers is particularly challenging to manage because it is resistant to the beneficial effects of inhaled corticosteroids, the main treatment for asthma. In view of the above, we propose to assess the effects of two different types of bronchodilators i.e. inhalers which help open up the airways, in asthmatics who continue to smoke.
- Current smoker
- Male or female aged 18-65, with asthma but not COPD
Title: MAN06 - Proof of concept study to assess downstream effects of using combined intranasal fluticasone propionate plus azelastine nasal spray on asthmatic inflammation in patients with persistent asthma and allergic rhinitis.
Description: Since most breathing is through the nose, we think that improving nasal stuffiness in people with allergic rhinitis and asthma, will in fact improve asthma control. This study tests standard asthma treatment and a dummy nasal spray, against standard asthma treatment and a steroid with antihistamine nasal spray.
- 18 years and above, no upper age limit
- Asthma and allergic rhinitis
Title: CPET1 - Chronic beta-blockade and cardiopulmonary exercise in COPD
Description: We are assessing if beta blockers (drugs that slow the heart rate down) will improve exercise capacity in people with COPD and also how the beta blockers affect breathing tests. We know beta blockers help heart problems, since the heart and lungs are closely connected, we believe there will be benefit in COPD also.
- COPD age 40-80, with a previous or current smoking history
Title: ANDA3 - Targeted small airway therapy in persistent asthma.
Description: We think that inhalers which dispense smaller particles of their medicine reach the lower parts of the lung better. In this study we compare an inhaler dispensing small particles of medicine versus an inhaler dispensing large particles of medicine, to see which is better on various breathing tests and asthma control.
- Male/female age 18-65 with asthma