Title: FOSTER-1 - Comparison of two formulations of beclometasone/formoterol pMDI on respiratory system impedance using impulse oscillometry in asthmatic patients
Description: The aim of the study is to compare two formulations of Fostair®. We will be looking at the effect of the two medications on breathing tests, asthma control questionnaires and blood tests. The main focus of the study is the impact of these two inhalers on a specific type of breathing test called impulse oscillometry (a gentle breathing test) and on a specific blood test called a pharmacokinetic profile (a blood test looking at what the body does to the drug).
- Current non-smoker or ex-smokers who stopped more than 1 year ago
- Male or female aged 18 or above with a diagnosis of persistent asthma for at least 6 months
- Further breathing tests may be required to determine eligibility
Title: MAN05 - Effects of ultra-long acting bronchodilator therapy assessed by impulse oscillometry in smoking asthmatics taking inhaled corticosteroids
Description: Cigarette smoking in asthma is associated with poorer asthma control and a higher frequency of asthma attacks. Asthma in smokers is particularly challenging to manage because it is resistant to the beneficial effects of inhaled corticosteroids, the main treatment for asthma. In view of the above, we propose to assess the effects of two different types of bronchodilators i.e. inhalers which help open up the airways, in asthmatics who continue to smoke.
- Current smoker
- Male or female aged 18-65, with asthma but not COPD
Title: CPET1 - Chronic beta-blockade and cardiopulmonary exercise in COPD
Description: We are assessing if beta blockers (drugs that slow the heart rate down) will improve exercise capacity in people with COPD and also how the beta blockers affect breathing tests. We know beta blockers help heart problems, since the heart and lungs are closely connected, we believe there will be benefit in COPD also.
- COPD age 40-80, with a previous or current smoking history